Autistic Children and Homocysteine Level


What is Homocysteine (HCY)?

Methylenetetrahydrofolate reductase is an enzyme that is encoded by the gene MTHFR. The MTHFR gene product plays an important role in the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This conversion reaction, which requires adequate intake of vitamin B12 and folate, is required for the multistep process that converts the amino acid homocysteine back to another amino acid, methionine.

Homocysteine is an amino acid and breakdown product of protein metabolism. Homocysteine is also produced in the body from another amino acid, methionine. One of the methionine’s main functions is to provide methyl groups for cellular reactions. Methionine is an essential amino acid that is found in meat and fish, for example. it plays a very important role in making sure that genes work properly. It does this by donating methyl groups that can be attached to cytosine residues, one of the building blocks of DNA. Attachment of methyl groups to DNA determines whether a gene is going to be expressed properly or not. When a methyl group is donated by methionine, it is eventually converted to the amino acid homocysteine. The reactions orchestrated by MTHFR described above re-methylate homocysteine and convert it back to methionine so that it can be used again to support the function of the genetic blueprint.

 

Homocysteine A Nasty Substance:

Decreased activity of MTHFR leads to inefficient conversion of homocysteine to methionine. Thus, suboptimal gene function of the gene MTHFR results in an increased level of homocysteine in the body.

The excess level of HCY inflicts damage to the inner arterial lining (endothelium) and other cells of the body. Elevated HCY level in the body causes inflammatory responses and cause inflammatory diseases like cardiovascular disease, arthritis, etc. High levels may also act on blood platelets and increase the risks of clot formation. Formation of plaque in the system is also due to the access of HCY in the system. In addition, some evidence suggests that people with elevated homocysteine levels have twice the normal risk of developing Alzheimer’s disease.

In simple terms, a methyl group is a chemical fragment consisting of one carbon and three hydrogen atoms. When methionine donates a methyl group for a cellular reaction, it becomes homocysteine. Typically, homocysteine then receives another methyl group from either folic acid or vitamin B12 to regenerate methionine.

Homocysteine Elimination Options:

From the above discussion, one can easily infer homocysteine is a nasty substance which needs to be eliminated through a natural elimination cycle as described above.

In the case of Autistic children, their body has a higher level of HCY than their healthy counterparts [1][2]. In conventional medicine, there is no drug which can eliminate the HCY level.

The Good news is in the realms of alternative healthcare. There are natural supplements and remedies which can help to overcome the excess level of homocysteine in the system. For example, a proper dose of Folic acid along with vitamins B12 may help in the elimination process of the excess of homocysteine [3], or by targeting and optimize the function of the MTHFR gene.

Contact your complimentary healthcare provider for more information.

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/29437021
  2. https://www.ncbi.nlm.nih.gov/pubmed/28598237
  3. https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12
More posts like this
Vaccine – Friend or Foe

Posted on August 18, 2019


A Short Take on Homeopathy

Posted on August 17, 2019


Liver – The Ultimate Recycler

Posted on August 14, 2019


Innovations In Homeopathy

Posted on August 6, 2019




Vaccine – Friend or Foe


In the conventional system of medicines inoculation, also known as vaccinations, is the universal method of immunization. Vaccinations stimulate the body’s own defence mechanism – the immune system, to protect a person against infectious diseases. A vaccinated person’s body produces an immune response in the form of antibodies against antigens. An antigen is a toxin or a foreign invader in the body. These antibodies eliminate the invading pathogens and expel them out of the body. Continue reading “Vaccine – Friend or Foe”

Liver – The Ultimate Recycler


On the right side of your body under the area of your ribs, if you put your right hand, this is where your liver is. The liver is the largest gland in the body. It holds over half-litre (one pint) of blood at any time and performs more than 500 functions. The liver is a dark reddish-brown organ comprises of two lobes. These lobes are further divided into smaller 100,000 lobes called lobules. Over 60% liver is made up of liver cells called hepatocytes, this is where detoxification processes occur and absorption of nutrients take place. Hepatic artery and portal vein supply blood to the liver.

Three-quarter of detoxification takes place in the liver and other one-quarter takes place in the intestine. This detoxification process is a very complex process. Let’s see how our liver under-takes this tremendous task of detoxification besides other activities. Continue reading “Liver – The Ultimate Recycler”

Innovations In Homeopathy


Gene Targeting Technology

Sequence Specific Homeopathic DNA (SSHD)

Gene Targeted – IL10

SSHD Molecule – IL10

Usage – Autoimmune Disorders

Potency – 6C

It has been the well-established fact that homeopathic remedies interact with gene expression. Specific DNA molecules have been prepared to target specific genes in order to optimise the function of the gene. Discoveries made by Prof. Khuda-Bukhsh [1], Saha and colleagues [2], Sunila and colleagues [3], Frenkel and colleagues [4] have shown that homeopathic remedies have the ability to interact with various mammalian genes and promote their expression. Furthermore, Nobel laureate Luc Montagnier has shown that highly diluted (i.e.; equivalent to 6C potency) DNA has telepathic properties and can transfer information between two DNA molecules which have the same sequence [5]. Continue reading “Innovations In Homeopathy”

Hyperactive Children – Neurologically Sick Children


Lack of concentration, impulsivity, fidgety, forgetfulness and daydreaming sometimes are normal traits in the behaviour of a child but these can also be attributed to a health problem when these signs start occurring more than normal in the behaviour of a young child. The clinical diagnosis for such symptoms is called Attention Deficit Hyperactivity Disorder (ADHD), sometimes known as Attention Deficit Disorder (ADD).

There is a long list of diagnosis with fancy medical terms like Neurodevelopmental Disorder (ND), Pervasive Developmental Disorder (PDD), specific developmental delay, tic disorder or hyperkinetic syndrome of childhood, and emotion Disturbance (ED), but the bottom line is all these medical terms points towards the malfunction of a person’s neurology. Continue reading “Hyperactive Children – Neurologically Sick Children”